Genomic investigations have enabled the partial understanding of phenotypic variability, a biological phenomenon naturally observed in any intervention of specific exposure. For example, the breadth of the benefits caused by diet and by physical training has substantial variation among individuals. This individual variation, explained partially by genetics and observed in any phenotype, may yet result in uncommon outcomes on populations submitted to elevated levels of an unusual exposure, as in the case of military police officers. With the purpose of exploring new knowledge in genomic science, a Cooperation Agreement in Research has been consolidated between the Heart Institute – InCor (HCFMUSP) and the Sao Paulo State Police Department (PMESP). Two thousand new PMESP recruits are being selected and will be evaluated throughout a period of 22 years. Adopting and exploratory and hypotheses-free approach for complete tracing of the human genome (microarray technology), part of our objectives includes to identify new genes, genetic variants and specific gene expression patterns that might be characterized as “molecular signatures and classifiers” of phenotypes: of trainability; of nutritional and neuropsycological profile; and cardiovascular. Comprehending the molecular mechanisms related to adaptive responses induced by physical training will allow soon to adapt therapeutical interventions in clinical practice, as well as to optimize physical training towards the maximal acquisition of performance in elite sport. At least these are some of this study’s purposes, involving genomics and sports science.

Researchers:

  • Rodrigo Gonçalves Dias (InCor)
  • Alexandre da Costa Pereira (InCor)
  • Silvia Beatriz C de Souza (InCor)
  • Michelle Sabrina Moreira dos Santos Silva (InCor)
  • Vera Maria Cury Salemi (InCor)
  • Renata dos Santos Corrêa (InCor)
  • José Ribeiro Lemos Júnior (InCor)
  • Edgar Toschi Dias (InCor)
  • Wladimir Bolani (InCor)
  • Jeferson Luis da Silva (InCor)
  • Lísia de Melo Pires Kiehl (USP)
  • Patrícia Alves de Oliveira (InCor)
  • Maria Janieire Nazaré Nunes Alves (InCor)
  • Carlos Eduardo Negrão (InCor)
  • José Eduardo Krieger (InCor)
  • Danilo Marcelo Leite do Prado (HCFMUSP)
  • Thiago da Costa Vieira Ciampone (Colaborator – Polícia Militar do Estado de São Paulo)
  • José Marques Novo Júnior (Colaborator – UFSCar)