{"id":4756,"date":"2023-04-27T19:21:55","date_gmt":"2023-04-27T19:21:55","guid":{"rendered":"https:\/\/genetica.incor.usp.br\/?p=4756"},"modified":"2023-05-02T15:58:12","modified_gmt":"2023-05-02T15:58:12","slug":"cardiogen-symposium","status":"publish","type":"post","link":"https:\/\/genetica.incor.usp.br\/?p=4756","title":{"rendered":"Expert meeting on precision medicine and cardiology presents promising advances in the field."},"content":{"rendered":"\r\n<!DOCTYPE html>\r\n<html xmlns=\"http:\/\/www.w3.org\/1999\/xhtml\" lang=\"en\" xml:lang=\"en\"><head>\r\n\r\n<meta charset=\"utf-8\">\r\n<meta name=\"generator\" content=\"quarto-1.2.335\">\r\n\r\n<meta name=\"viewport\" content=\"width=device-width, initial-scale=1.0, user-scalable=yes\">\r\n\r\n\r\n<title>en-us-materia_simposium<\/title>\r\n<style>\r\ncode{white-space: pre-wrap;}\r\nspan.smallcaps{font-variant: small-caps;}\r\ndiv.columns{display: flex; gap: min(4vw, 1.5em);}\r\ndiv.column{flex: auto; overflow-x: auto;}\r\ndiv.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}\r\nul.task-list{list-style: none;}\r\nul.task-list li input[type=\"checkbox\"] {\r\n  width: 0.8em;\r\n  margin: 0 0.8em 0.2em -1.6em;\r\n  vertical-align: middle;\r\n}\r\n<\/style>\r\n\r\n\r\n<script src=\"EN-US materia_simposium_files\/libs\/clipboard\/clipboard.min.js\"><\/script>\r\n<script src=\"EN-US materia_simposium_files\/libs\/quarto-html\/quarto.js\"><\/script>\r\n<script src=\"EN-US materia_simposium_files\/libs\/quarto-html\/popper.min.js\"><\/script>\r\n<script src=\"EN-US materia_simposium_files\/libs\/quarto-html\/tippy.umd.min.js\"><\/script>\r\n<script src=\"EN-US materia_simposium_files\/libs\/quarto-html\/anchor.min.js\"><\/script>\r\n<link href=\"EN-US materia_simposium_files\/libs\/quarto-html\/tippy.css\" rel=\"stylesheet\">\r\n<link href=\"EN-US materia_simposium_files\/libs\/quarto-html\/quarto-syntax-highlighting.css\" rel=\"stylesheet\" id=\"quarto-text-highlighting-styles\">\r\n<script src=\"EN-US materia_simposium_files\/libs\/bootstrap\/bootstrap.min.js\"><\/script>\r\n<link href=\"EN-US materia_simposium_files\/libs\/bootstrap\/bootstrap-icons.css\" rel=\"stylesheet\">\r\n<link href=\"EN-US materia_simposium_files\/libs\/bootstrap\/bootstrap.min.css\" rel=\"stylesheet\" id=\"quarto-bootstrap\" data-mode=\"light\">\r\n\r\n<\/head>\r\n\r\n<body class=\"fullcontent\">\r\n\r\n<div id=\"quarto-content\" class=\"page-columns page-rows-contents page-layout-article\">\r\n\r\n<main class=\"content\" id=\"quarto-document-content\">\r\n\r\n\r\n\r\n<hr>\r\n<div style=\"display: flex;\">\r\n<div style=\"flex: 1; padding: 10px;\">\r\n<p>On Saturday, April 15th, an important event organized by the team of the Laboratory of Genetics and Molecular Cardiology of the Heart Institute (LGCM-InCor), located at the Hospital das Cl\u00ednicas of USP, took place to discuss the advances of precision medicine. The symposium featured renowned medical experts and aimed to present the latest advances in precision medicine, as well as to discuss the implementation of these techniques in clinical practice.<\/p>\r\n<\/div>\r\n  <div style=\"flex: 1; padding: 10px;border-left: 10px solid #ed1c24; border-top: 1px solid #dcdcdc; border-bottom: 1px solid #dcdcdc; border-right: 1px solid #dcdcdc; border-radius: 4px; display: flex; align-items: stretch; background-color: #ffffff;\">\r\n  <div class=\"callout-copyright callout callout-style-default no-icon callout-captioned\">\r\n  <div class=\"callout-header d-flex align-content-center\">\r\n  <div class=\"callout-icon-container\">\r\n  <i class=\"callout-icon no-icon\"><\/i>\r\n  <\/div>\r\n  <div class=\"callout-caption-container flex-fill\">\r\n  <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 24 24\" width=\"96\" height=\"40\"><path d=\"M4.58341 17.3211C3.55316 16.2275 3 15 3 13.0104C3 9.51092 5.45651 6.37372 9.03059 4.82324L9.92328 6.20085C6.58804 8.00545 5.93618 10.3461 5.67564 11.8221C6.21263 11.5444 6.91558 11.4467 7.60471 11.5106C9.40908 11.6778 10.8312 13.1591 10.8312 15C10.8312 16.933 9.26416 18.5 7.33116 18.5C6.2581 18.5 5.23196 18.0096 4.58341 17.3211ZM14.5834 17.3211C13.5532 16.2275 13 15 13 13.0104C13 9.51092 15.4565 6.37372 19.0306 4.82324L19.9233 6.20085C16.588 8.00545 15.9362 10.3461 15.6756 11.8221C16.2126 11.5444 16.9156 11.4467 17.6047 11.5106C19.4091 11.6778 20.8312 13.1591 20.8312 15C20.8312 16.933 19.2642 18.5 17.3312 18.5C16.2581 18.5 15.232 18.0096 14.5834 17.3211Z\" fill=\"#ed1c24\"><\/path><\/svg>\r\n  <\/div>\r\n  <\/div>\r\n  <div class=\"callout-body-container callout-body\">\r\n  <p style=\"color: #ed1c24;font-size:20px; text-align: left;\">\r\n  <strong>Precision medicine<\/strong> is a personalized approach to medicine that uses genetic, molecular, and clinical information to tailor the diagnosis, treatment, and prevention of diseases in individuals.\r\n  <\/p>\r\n  <\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<p>The opening and coordination of the event were led by <a href=\"https:\/\/genetica.incor.usp.br\/?uid=119&amp;page_id=3208\">Dr.&nbsp;Jos\u00e9 Eduardo Krieger<\/a>, director of LGCM and one of the most renowned cardiologists in the country. Precision medicine is an innovative approach that uses genetic, molecular, and clinical information to personalize the diagnosis, treatment, and prevention of diseases, bringing significant benefits to patients and healthcare professionals.The Symposium was an opportunity for professionals to update their knowledge in this constantly evolving field and share experiences on the implementation of precision medicine with the <a href=\"https:\/\/genetica.incor.usp.br\/?page_id=4132\">CardioGen<\/a> project team at LGCM.<\/p>\r\n<section id=\"what-happened-during-the-meeting\" class=\"level2\">\r\n<h2 class=\"anchored\" data-anchor-id=\"what-happened-during-the-meeting\"><strong>What happened during the meeting?<\/strong><\/h2>\r\n<div style=\"display: flex;\">\r\n<div style=\"flex: 1; padding: 10px;\">\r\n<div class=\"callout-fig callout callout-style-default no-icon callout-captioned\">\r\n<div class=\"callout-header d-flex align-content-center\">\r\n<div class=\"callout-icon-container\">\r\n<i class=\"callout-icon no-icon\"><\/i>\r\n<\/div>\r\n<div class=\"callout-caption-container flex-fill\" style=\"color: cornsilk;\">\r\nCardioGen Symposium\r\n<\/div>\r\n<\/div>\r\n<div class=\"callout-body-container callout-body\">\r\n \r\n<p style=\"font-size: small;color: darkgrey;\">The symposium featured the participation of CardioGen&#8217;s staff led by Dr. Jos\u00e9 Krieger. The event had the presence of renowned international scientists and culminated in a hands-on where the team demonstrated the functioning of the precision medicine center.<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div style=\"flex: 1; padding: 10px;\">\r\n<p>The event featured four modules covering aortopathies, arrhythmias, cardiomyopathies, and dyslipidemias in relation to genetic testing. Experts discussed indications for genetic testing, impacts on diagnoses and treatments, as well as presented clinical cases. After each module, there was a discussion session.<\/p>\r\nDuring the lectures of the first module, the state-of-the-art in TTR amyloidosis and gene-guided treatment were discussed. The role of genetic testing in non-ischemic cardiomyopathies and the prognostic impact of positive genetic testing in hypertrophic cardiomyopathy were also addressed. In this segment, we had the participation of <a href=\"https:\/\/genetica.incor.usp.br\/?uid=1085&amp;page_id=3208\">Dr.&nbsp;Fernanda Andrade<\/a>, cardiologist and CardioGen team member.\r\n<\/div>\r\n<\/div>\r\n<p>Throughout the schedule, other members of the team joined the discussion such as <a href=\"https:\/\/genetica.incor.usp.br\/?uid=1102&amp;page_id=3208\">Dr.&nbsp;Marjorie Mizuta<\/a>, <a href=\"https:\/\/genetica.incor.usp.br\/?uid=1112&amp;page_id=3208\">Dr.&nbsp;Silas Furquim<\/a>, <a href=\"https:\/\/genetica.incor.usp.br\/?uid=108&amp;page_id=3208\">Dr.&nbsp;Luciana Sacilotto<\/a>, <a href=\"https:\/\/genetica.incor.usp.br\/?uid=1113&amp;page_id=3208\">Dr.&nbsp;Layara Lipari<\/a>, <a href=\"https:\/\/genetica.incor.usp.br\/?uid=1086&amp;page_id=3208\">Dr.&nbsp;Fernando Giugni<\/a>, <a href=\"https:\/\/genetica.incor.usp.br\/?uid=405&amp;page_id=3208\">Dr.&nbsp;Nat\u00e1lia Olivetti<\/a>, <a href=\"https:\/\/genetica.incor.usp.br\/?uid=1103&amp;page_id=3208\">Dra. Bianca Linnenkamp<\/a> and <a href=\"https:\/\/genetica.incor.usp.br\/?uid=1116&amp;page_id=3208\">Dr.&nbsp;Lucas Vieira<\/a>.Among the topics discussed by the specialists, the relationship between genetic testing and dyslipidemia drew attention. Aspects such as risk scores for hypercholesterolemia or PCSK9 inhibitors <a href=\"https:\/\/genetica.incor.usp.br\/?p=4715\">(Learn more about PCSK9)<\/a> were part of the discussion among the laboratory experts and invited professionals.<\/p>\r\n<p>The event also featured international guests who brought valuable information on cardiomyopathies and forensic medicine. Professor Dr.&nbsp;Andrea Mazzanti from the University of Pavia in Italy presented a lecture titled \u201cGenetic Testing in Cardiomyopathies: Have We Arrived?\u201d. Professor Dr.&nbsp;Christopher Semsarian from the University of Sydney in Australia gave a talk on how to engage Brazilian doctors in the important task of molecular autopsy in victims of sudden cardiac death. Both lectures were extremely informative and made significant contributions to the event\u2019s discussion.<\/p>\r\n<p>As part of the continuing education for the professionals who attended the symposium, the CardioGen team offered a hands-on experience consisting of five practical stations that covered different aspects of genetic counseling and genomic analysis. The first station presented pre-test counseling to guide patients on the risks and benefits of genetic testing. The second station demonstrated DNA extraction and NGS sequencing. The third station addressed genetic variant classification and its importance in interpreting results. The fourth station discussed post-test counseling to help patients understand the results of genetic testing. Finally, the fifth station covered clinical screening of family members through exams such as ECG and echocardiography. The hands-on experience ended at 4:10 pm with final discussions.<\/p>\r\n<\/section>\r\n<section id=\"precision-medicine-at-lgcm\" class=\"level2\">\r\n<h2 class=\"anchored\" data-anchor-id=\"precision-medicine-at-lgcm\"><strong>Precision Medicine at LGCM<\/strong><\/h2>\r\n<p><a href=\"https:\/\/cardiogen-incor.com.br\/o-centro\/\">CardioGen<\/a> is a multidisciplinary group specialized in healthcare for patients with genetic cardiovascular diseases, operating at the Heart Institute of S\u00e3o Paulo (InCor), HC-FMUSP. Composed of cardiologists, geneticists, biologists, and biomedical professionals, the team is led by Professor Dr.&nbsp;Jos\u00e9 Eduardo Krieger, full professor of Genetics and Molecular Cardiology at the University of S\u00e3o Paulo School of Medicine. CardioGen provides Precision Cardiology services, including genetic counseling, genetic and molecular testing, and multiprofessional outpatient care. The approach is humanized, integrated, and personalized.<\/p>\r\n<p>Dr.&nbsp;Lucas Vieira is one of the geneticists on the team and adds that CardioGen is a pioneering initiative in both the clinical and medical genetics fields. He hopes that in the short term, the team can provide more information about precision medicine to other professionals, and in the long term, these professionals will form other multidisciplinary teams that involve geneticists, cardiologists, and bioinformaticians that promote Brazilian precision medicine to the world.<\/p>\r\n<p>\u201c<em>\u2026Precision medicine offers numerous opportunities for scientific development within the medical field, and it is a new area that is beginning to move the world\u2026\u201c<\/em> \u2014 said the physician.<\/p>\r\n<\/section>\r\n\r\n<\/main>\r\n<!-- \/main column -->\r\n<script id=\"quarto-html-after-body\" type=\"application\/javascript\">\r\nwindow.document.addEventListener(\"DOMContentLoaded\", function (event) {\r\n  const toggleBodyColorMode = (bsSheetEl) => {\r\n    const mode = bsSheetEl.getAttribute(\"data-mode\");\r\n    const bodyEl = window.document.querySelector(\"body\");\r\n    if (mode === \"dark\") {\r\n      bodyEl.classList.add(\"quarto-dark\");\r\n      bodyEl.classList.remove(\"quarto-light\");\r\n    } else {\r\n      bodyEl.classList.add(\"quarto-light\");\r\n      bodyEl.classList.remove(\"quarto-dark\");\r\n    }\r\n  }\r\n  const toggleBodyColorPrimary = () => {\r\n    const bsSheetEl = window.document.querySelector(\"link#quarto-bootstrap\");\r\n    if (bsSheetEl) {\r\n      toggleBodyColorMode(bsSheetEl);\r\n    }\r\n  }\r\n  toggleBodyColorPrimary(); 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<\/p>\n<p class=\"link-more\"><a href=\"https:\/\/genetica.incor.usp.br\/?p=4756\" class=\"more-link\">Read more<span class=\"screen-reader-text\"> &#8220;Expert meeting on precision medicine and cardiology presents promising advances in the field.&#8221;<\/span><\/a><\/p>\n","protected":false},"author":473,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-4756","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/posts\/4756","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/users\/473"}],"replies":[{"embeddable":true,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4756"}],"version-history":[{"count":6,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/posts\/4756\/revisions"}],"predecessor-version":[{"id":4855,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/posts\/4756\/revisions\/4855"}],"wp:attachment":[{"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4756"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4756"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4756"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}