{"id":832,"date":"2013-12-12T13:08:00","date_gmt":"2013-12-12T13:08:00","guid":{"rendered":"http:\/\/172.21.65.35:8680\/wordpress\/?p=832"},"modified":"2021-05-18T13:11:30","modified_gmt":"2021-05-18T13:11:30","slug":"advances-in-genomics-for-molecular-diagnoses-a-longitudinal-study-of-a-special-exposure-cohort-with-the-sao-paulo-state-police-department-effective","status":"publish","type":"post","link":"https:\/\/genetica.incor.usp.br\/?p=832","title":{"rendered":"Advances In Genomics For Molecular Diagnoses: A Longitudinal Study Of A Special Exposure Cohort With The Sao Paulo State Police Department Effective"},"content":{"rendered":"<style>.grid-container { margin-top: 20px;display: grid; grid-template-columns: auto auto auto; grid-template-rows: auto; grid-column-gap: 20px; grid-row-gap: 20px;} .grid-item {padding: 0px;}<\/style>Genomic investigations have enabled the partial understanding of phenotypic variability, a biological phenomenon naturally observed in any intervention of specific exposure. For example, the breadth of the benefits caused by diet and by physical training has substantial variation among individuals. This individual variation, explained partially by genetics and observed in any phenotype, may yet result in uncommon outcomes on populations submitted to elevated levels of an unusual exposure, as in the case of military police officers. With the purpose of exploring new knowledge in genomic science, a Cooperation Agreement in Research has been consolidated between the Heart Institute \u2013 InCor (HCFMUSP) and the Sao Paulo State Police Department (PMESP). Two thousand new PMESP recruits are being selected and will be evaluated throughout a period of 22 years. Adopting and exploratory and hypotheses-free approach for complete tracing of the human genome (microarray technology), part of our objectives includes to identify new genes, genetic variants and specific gene expression patterns that might be characterized as \u201cmolecular signatures and classifiers\u201d of phenotypes: of trainability; of nutritional and neuropsycological profile; and cardiovascular. Comprehending the molecular mechanisms related to adaptive responses induced by physical training will allow soon to adapt therapeutical interventions in clinical practice, as well as to optimize physical training towards the maximal acquisition of performance in elite sport. At least these are some of this study\u2019s purposes, involving genomics and sports science.\n<div class=\"grid-container\">\n<div class=\"grid-item\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"http:\/\/172.21.65.35:8680\/wordpress\/wp-content\/uploads\/2021\/05\/Slide7.jpg\"><\/div>\n<div class=\"grid-item\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"http:\/\/172.21.65.35:8680\/wordpress\/wp-content\/uploads\/2021\/05\/Slide5.jpg\"><\/div>\n<div class=\"grid-item\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"http:\/\/172.21.65.35:8680\/wordpress\/wp-content\/uploads\/2021\/05\/Slide31.jpg\"><\/div>\n<div class=\"grid-item\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"http:\/\/172.21.65.35:8680\/wordpress\/wp-content\/uploads\/2021\/05\/Slide101.jpg\"><\/div>\n<div class=\"grid-item\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"http:\/\/172.21.65.35:8680\/wordpress\/wp-content\/uploads\/2021\/05\/Slide21.jpg\"><\/div>\n<div class=\"grid-item\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"http:\/\/172.21.65.35:8680\/wordpress\/wp-content\/uploads\/2021\/05\/Slide22.jpg\"><\/div>\n<div class=\"grid-item\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"http:\/\/172.21.65.35:8680\/wordpress\/wp-content\/uploads\/2021\/05\/Slide13.jpg\"><\/div>\n<div class=\"grid-item\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"http:\/\/172.21.65.35:8680\/wordpress\/wp-content\/uploads\/2021\/05\/Slide18.jpg\"><\/div>\n<div class=\"grid-item\">\n        <img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"http:\/\/172.21.65.35:8680\/wordpress\/wp-content\/uploads\/2021\/05\/Slide14.jpg\"><\/div>\n<\/div>\n<strong>Researchers: <\/strong>\n<ul>\n \t<li>Rodrigo Gon\u00e7alves Dias (InCor)<\/li>\n \t<li>Alexandre da Costa Pereira (InCor)<\/li>\n \t<li>Silvia Beatriz C de Souza (InCor)<\/li>\n \t<li>Michelle Sabrina Moreira dos Santos Silva (InCor)<\/li>\n \t<li>Vera Maria Cury Salemi (InCor)<\/li>\n \t<li>Renata dos Santos Corr\u00eaa (InCor)<\/li>\n \t<li>Jos\u00e9 Ribeiro Lemos J\u00fanior (InCor)<\/li>\n \t<li>Edgar Toschi Dias (InCor)<\/li>\n \t<li>Wladimir Bolani (InCor)<\/li>\n \t<li>Jeferson Luis da Silva (InCor)<\/li>\n \t<li>L\u00edsia de Melo Pires Kiehl (USP)<\/li>\n \t<li>Patr\u00edcia Alves de Oliveira (InCor)<\/li>\n \t<li>Maria Janieire Nazar\u00e9 Nunes Alves (InCor)<\/li>\n \t<li>Carlos Eduardo Negr\u00e3o (InCor)<\/li>\n \t<li>Jos\u00e9 Eduardo Krieger (InCor)<\/li>\n \t<li>Danilo Marcelo Leite do Prado (HCFMUSP)<\/li>\n \t<li>Thiago da Costa Vieira Ciampone (Colaborator \u2013 Pol\u00edcia Militar do Estado de S\u00e3o Paulo)<\/li>\n \t<li>Jos\u00e9 Marques Novo J\u00fanior (Colaborator \u2013 UFSCar)<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Genomic investigations have enabled the partial understanding of phenotypic variability, a biological phenomenon naturally observed in any intervention of specific exposure. For example, the breadth of the benefits caused by &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/genetica.incor.usp.br\/?p=832\" class=\"more-link\">Read more<span class=\"screen-reader-text\"> &#8220;Advances In Genomics For Molecular Diagnoses: A Longitudinal Study Of A Special Exposure Cohort With The Sao Paulo State Police Department Effective&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":862,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-832","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/posts\/832","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=832"}],"version-history":[{"count":0,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/posts\/832\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=\/wp\/v2\/media\/862"}],"wp:attachment":[{"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=832"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=832"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/genetica.incor.usp.br\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}