André Brooking Negrão

Short Bio

ANDRE B. NEGRÃO graduated from University of São Paulo Medical School in 1990, completed his residency training in Psychiatry in 1994 at the Institute and Department of Psychiatry at USP. He was a clinical associate investigator at the Clinical Endocrinology Branch, National Institute of Mental Health (NIMH, NIH) in Bethesda, MD from 1995 to 2000 where he participated in five research projects and coordinated 2 of them. Published 22 papers, 27 abstracts in conference proceedings and 6 book chapters. Among the most significant projects is the use of natural stressors to elicit neuroendocrine responses in normal subjects and patients with psychiatric disorders. From 2003 to 2007, he coordinated clinical care and research groups in substance dependence outpatient clinics at USP and UNIFESP. He obtained his PhD at University of São Paulo Medical School in 2012 investigating genetic markers and crack/cocaine dependence. He helds a post doctoral position at the Laboratório de Genética e Cardiologia Molecular, InCor-HCFMUSP, investigating the heritability of various human behavior phenotypes.

Line of Investigation

  • Herdabilidade de sintomas ansiosos e depressivos em coortes oriundas da população geral


  1. MORGAN, C. M.;VECCHIATTI, I. R.;NEGRÃO, A. B.;.Etiologia dos transtornos alimentares: aspectos biológicos, psicológicos e sócio-culturais. Revista Brasileira de Psiquiatria (São Paulo. 1999. Impresso),v.24,18,2002;
  2. TAPOROSKI, TÂMARA P.;Negrão, André B.;HORIMOTO, ANDRÉA R. V. R.;DUARTE, NUBIA E.;ALVIM, RAFAEL O.;DE OLIVEIRA, CAMILA M.;KRIEGER, JOSÉ E.;SCHANTZ, MALCOLM VON;VALLADA, HOMERO;PEREIRA, ALEXANDRE C.;.Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study. Plos One,v.10,e0144255,2015;
  3. LICINIO, J;NEGRAO, A B;WONG, M-L;.Plasma leptin concentrations are highly correlated to emotional states throughout the day. Translational Psychiatry,v.4,e475,2014;
  4. VON SCHANTZ, MALCOLM;TAPOROSKI, TAMARA P.;HORIMOTO, ANDRÉA R. V. R.;DUARTE, NUBIA E.;VALLADA, HOMERO;KRIEGER, JOSÉ E.;PEDRAZZOLI, MARIO;Negrão, André B.;PEREIRA, ALEXANDRE C.;.Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study. Scientific Reports,v.5,9214,2015;
  5. NEGRÃO, ANDRÉ BROOKING;PEREIRA, ALEXANDRE COSTA;GUINDALINI, CAMILA;SANTOS, HADASSA CAMPOS;MESSAS, GUILHERME PERES;LARANJEIRA, RONALDO;VALLADA, HOMERO;.Butyrylcholinesterase Genetic Variants: Association with Cocaine Dependence and Related Phenotypes. Plos One,v.8,e80505,2013;
  6. NEGRÃO, A. B.;.Transtornos alimentares e obesidade. Revista Brasileira de Psiquiatria (São Paulo. 1999. Impresso),v.29,96,2007;
  7. POPE, H. G. Jr.;MANGWETH, B.;NEGRÃO, A. B.;HUDSON, J. I.;CORDAS, T. A.;.Childhood sexual abuse and bulimia nervosa: a comparison of American, Austrian, and Brazilian women. The American Journal of Psychiatry,v.151,732 - 737,1994;
  8. BORNSTEIN, S. R.;LICINIO, J.;TAUCHNITZ, R.;ENGELMANN, L.;NEGRÃO, A. B.;GOLD, P. W.;CHROUSOS, G. P.;.Plasma Leptin Levels Are Increased in Survivors of Acute Sepsis: Associated Loss of Diurnal Rhythm in Cortisol and Leptin Secretion. The Journal of Clinical Endocrinology and Metabolism,v.83,280 - 283,1998;
  9. CORDAS, T. A.;NEGRÃO, A. B.;CASTILHO, S. M.;.Clinical characteristics and course of anorexia nervosa in Latin America, a Brazilian sample. Jornal Brasileiro de Psiquiatria,v.41,303 - 304,1992;
  10. NEGRÃO, A. B.;CORDAS, T. A.;.Clinical characteristics and course of anorexia nervosa in Latin America, a Brazilian sample. Psychiatry Research (Print),v.62,17 - 21,1996;
  11. NEGRÃO, A. B.;LICINIO, J.;.Stress-responsive neuropeptides in major depression. Molecular Psychiatry,v.1,300 - 3001,1996;
  12. LICINIO, J.;MANTZOROS, C.;NEGRÃO, A. B.;CIZZA, G.;WONG, M-L.;BONGIORNO, P. B.;CHROUSOS, G. P.;KARP, B.;ALLEN, C.;FLIER, J. S.;GOLD, P. W.;.Human leptin levels are pulsatile and inversely related to pituitary-ardenal function. Nature Medicine (Print),v.3,575 - 579,1997;
  13. NEGRÃO, A. B.;.Mood disorders across the continents. Molecular Psychiatry,v.2,439 - 441,1997;
  14. LICINIO, J.;NEGRÃO, A. B.;MANTZOROS, C.;KAKLAMANI, V.;WONG, M-L.;BONGIORNO, P. B.;MULLA, A.;CEARNAL, L.;VELDHUIS, J. D.;FLIER, J. S.;MCCANN, S. M.;GOLD, P. W.;.Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. Proceedings of the National Academy of Sciences of the United States of America,v.95,2541 - 2546,1998;
  15. ASBAHR, F. R.;NEGRÃO, A. B.;GENTIL FILHO, V.;ZANETTA, D. M. T.;PAZ, J. A.;MARQUES-DIAS, M. J.;KISS, M. H.;.Obsessive-Compulsive and Related Symptoms in Children and Adolescents With Rheumatic Fever With and Without Chorea: A Prospective 6-Month Study. The American Journal of Psychiatry,v.155,1122 - 1124,1998;
  16. LICINIO, J.;NEGRÃO, A. B.;MANTZOROS, C.;KAKLAMANI, V.;WONG, M-L.;BONGIORNO, P. B.;NEGRO, P. P.;MULLA, A.;VELDHUIS, J. D.;CEARNAL, L.;FLIER, J. S.;GOLD, P. W.;.Sex Differences in Circulating Human Leptin Pulse Amplitude: Clinical Implications. The Journal of Clinical Endocrinology and Metabolism,v.83,4140 - 4147,1998;
  17. NEGRÃO, A. B.;LICINIO, J.;MANTZOROS, C.;WONG, M-L.;NEGRO, P.;CEARNAL, L.;GOLD, P. W.;.Diferenças na secreção diária de leptina em homens e mulheres: possíveis implicações na neuroendocrinologia dos transtornos alimentares. Revista de Psiquiatria Clínica,v.25,184 - 190,1998;
  18. NEGRÃO, A. B.;LICINIO, J.;.Psiquiatria na próxima década. Revista USP,v.43,60 - 69,1999;
  19. ASBAHR, F. R.;RAMOS, R. T.;NEGRÃO, A. B.;GENTIL FILHO, V.;.Case Series: Increased Vulnerability to Obsessive-Compulsive Symptoms With Repeated Episodes of Sydenham Chorea. Journal of the American Academy of Child and Adolescent Psychiatry,v.38,1522 - 1525,1999;
  20. NEGRÃO, A. B.;LICINIO, J.;.Obesity: on the eve of a major conceptual revolution. Drug Discovery Today,v.5,177 - 179,2000;
  21. NEGRÃO, A. B.;DEUSTER, P. A.;GOLD, P. W.;SINGH, A.;CHROUSOS, G. P.;.Individual reactivity and physiology of the stress response. Biomedicine & Pharmacotherapy,v.54,122 - 128,2000;
  22. MANTZOROS, C.;OZATA, M.;NEGRÃO, A. B.;SUCHARD, M. A.;ZIOTOPOULOU, M.;CAGLAYAN, S.;ELASHOFF, R. M.;COGSWELL, R. J.;NEGRO, P.;LIBERTY, V.;WONG, M-L.;VELDHUIS, J. D.;OZDEMIR, I. C.;GOLD, P. W.;FLIER, J. S.;.Synchronicity of Frequently Sampled Thyrotropin (TSH) and Leptin Concentrations in Healthy Adults and Leptin-Deficient Subjects: Evidence for Possible Partial TSH Regulation by Leptin in Humans. The Journal of Clinical Endocrinology and Metabolism,v.86,3284 - 3291,2001;
  23. GABRY, K. E.;CHROUSOS, G. P.;RICE, K. C.;MOSTAFA, R. M.;STERNBERG, E.;NEGRÃO, A. B.;WEBSTER, E. L.;MCCANN, S. M.;GOLD, P. W.;.Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs. Molecular Psychiatry,v.7,474 - 483,2002;
  24. RASGON, N. L.;PUMPHREY, L.;PROLO, P.;ELMAN, S.;NEGRÃO, A. B.;LICINIO, J.;GARFINKEL, A.;.Emergent oscillations in a mathematical model of the human menstrual cycle. CNS Spectrums,v.8,805 - 814,2003;
  25. ALVARENGA, M. S.;NEGRÃO, A. B.;PHILIPPI, S. T.;.Nutritional aspects of eating episodes followed by vomiting in Brazilian patients with bulimia nervosa. Eating and Weight Disorders (Printed text),v.8,150 - 156,2003;