Ayumi Miyakawa

Short Bio

Bachelor's in Biomedical Sciences (1995) and Ph.D. in Molecular Biology (2000) at Federal University of Sao Paulo (UNIFESP-EPM). Pos-Doctoral Fellow at Heart Institute (InCor - University of Sao Paulo Medical School - HCFMUSP), Research Fellow at Brigham and Women´s Hospital and Harvard Medical School (2010-2012) and Research Affiliated at Harvard-MIT Division of Health Sciences and Technology (2010-2012). She is a Principal Investigator in the Laboratory og Genetics and Molecular Cardiology and coordinates the Vascular Biology group focused on mechanotransduction and vascular remodeling.

Line of Investigation

  • Vascular mechanotransduction
  • Identification and characterization of genes and proteins modulated during vein-graft arterialization

Publications

  1. Barauna, Valerio Garrone;CAMPOS, Luciene Cristina Gastalho;MIYAKAWA, Ayumi Aurea;KRIEGER, Jose Eduardo;.ACE as a Mechanosensor to Shear Stress Influences the Control of Its Own Regulation via Phosphorylation of Cytoplasmic Ser1270. Plos One,v.6,e22803,2011;
  2. MARCHINI, JULIO F.;Miyakawa, Ayumi Aurea;TARASOUTCHI, FLAVIO;KRIEGER, José Eduardo;LEMOS, PEDRO;CROCE, KEVIN;.Endothelial, platelet, and macrophage microparticle levels do not change acutely following transcatheter aortic valve replacement. Journal of Negative Results In Biomedicine,v.15,7,2016;
  3. DE FAZIO AGUIAR, HELENA;JÚNIOR, ANTONIO CARLOS ROVEDA;DE JESUS PIVA, RENAN;ONODA, KEVIN AKIRA;Miyakawa, Ayumi Aurea;KRIEGER, Jose Eduardo;FRANCO, DOUGLAS WAGNER;TADINI, CARMEN CECILIA;.Compatibility of cassava starch films as nitric oxide carrier for potential medical device. Journal of Applied Polymer Science (Print),v.132,n/a - n/a,2015;
  4. GIRÃO-SILVA, THAIS;BASSANEZE, Vinicius;CAMPOS, LUCIENE CRISTINA;Barauna, Valerio Garrone;DALLAN, LUIS ALBERTO;KRIEGER, Jose Eduardo;Miyakawa, Ayumi Aurea;.Short-term mechanical stretch fails to differentiate human adipose-derived stem cells into cardiovascular cell phenotypes. Biomedical Engineering Online (Online),v.13,54,2014;
  5. BARAUNA, VALERIO G.;MAGALHAES, FLÁVIO C.;Campos, Luciene C.G.;REIS, ROSANA I.;KUNAPULI, SATYA P.;COSTA-NETO, CLAUDIO M.;MIYAKAWA, AYUMI A.;KRIEGER, JOSE E.;.Shear stress-induced Ang II AT1 receptor activation: G-protein dependent and independent mechanisms. Biochemical and Biophysical Research Communications (Print),v.434,647 - 652,2013;
  6. Ferreira, Noely E;Omae, Samantha;Pereira, Abel;Rodrigues, Mariliza V.;MIYAKAWA, Ayumi Aurea;Campos, Luciene C.G.;Santos, Paulo C.J.L.;Dallan, Luiz A.;Martinez, Tania L;Santos, Raul D.;Mill, Jose G;KRIEGER, Jose Eduardo;Pereira, Alexandre C.;.Thioredoxin interacting protein genetic variation is associated with diabetes and hypertension in the Brazilian general population. Atherosclerosis (Amsterdam),v.221,131 - 136,2012;
  7. MIYAKAWA, Ayumi Aurea;BASSANEZE, Vinicius;NAKAMUTA, J. S.;SANTOS-JUNIOR, G. R.;SAINT-CLAIR, D.;BAJGELMAN, M. C.;FAE, K. C.;KALIL, J.;KRIEGER, José Eduardo;.Adipose Tissue-Derived Stem Cells from Humans and Mice Differ in Proliferative Capacity and Genome Stability in Long-Term Cultures. Stem Cells and Development,v.20,661 - 670,2011;
  8. MIYAKAWA, Ayumi Aurea;BARAUNA, V. G.;Lavini-Ramos, C;KALIL, J.;Schettert, I.T.;KRIEGER, José Eduardo;.Shear Stress Induces Nitric Oxide-Mediated Vascular Endothelial Growth Factor Production in Human Adipose Tissue Mesenchymal Stem Cells. Stem Cells and Development,v.19,371 - 378,2010;
  9. MIYAKAWA, Ayumi Aurea;BASSANEZE, Vinicius;Lavini-Ramos, C;FAE, K. C.;KALIL, J.;Schettert, I.T.;KRIEGER, Jose Eduardo;.TRANSPLANTATION AND CELLULAR ENGINEERING: Adipose tissue mesenchymal stem cell expansion in animal serum-free medium supplemented with autologous human platelet lysate. Transfusion (Arlington, Va.),v.49,2680 - 2685,2009;
  10. CAMPOS, Luciene Cristina Gastalho;MIYAKAWA, Ayumi Aurea;BARAUNA, V. G.;CARDOSO, L.;BORIN, Thaiz Ferraz;DALLAN, Luís Alberto Oliveira;KRIEGER, José Eduardo;.Induction of CRP3/MLP expression during vein arterialization is dependent on stretch rather than shear stress. Cardiovascular Research,v.83,140 - 147,2009;
  11. BORIN, Thaiz Ferraz;MIYAKAWA, Ayumi Aurea;CARDOSO, L.;BORGES, L. F.;GONÇALVES, G. A.;KRIEGER, José Eduardo;.Apoptosis, cell proliferation and modulation of cyclin-dependent kinase inhibitor p21cip1 in vascular remodelling during vein arterialization in the rat. International Journal of Experimental Pathology,v.90,328 - 337,2009;
  12. MIYAKAWA, Ayumi Aurea;DALLAN, Luis Alberto Oliveira;Lacchini, Silvia;BORIN, Thaiz Ferraz;KRIEGER, Jose Eduardo;.Human saphenous vein organ culture under controlled hemodynamic conditions. Clinics (São Paulo),v.63,683 - 688,2008;
  13. NEUKAMM, Birgit;MIYAKAWA, Ayumi Aurea;FUKADA, Sandra;ANDRADE, Claudia R;PACHECO, Fernando Pasquali;SILVA, T. G.;RAMALHO, Leandra N Z;OLIVEIRA, Ana Maria;KRIEGER, Jose Eduardo;.Local TAT-p27kip fusion protein inhibits cell proliferation in rat carotid arteries. Therapeutic Advances in Cardiovascular Disease (Print),v.2,129 - 136,2008;
  14. BASSANEZE, Vinicius;MIYAKAWA, Ayumi Aurea;KRIEGER, Jose Eduardo;.A quantitative chemiluminescent method for studying replicative and stress-induced premature senescence in cell cultures.. Analytical Biochemistry,v.372,198 - 203,2008;
  15. PEREIRA, A. C.;MIYAKAWA, Ayumi Aurea;Lopes, NH;Soares, PR;OLIVEIRA, Sérgio de Almeida;Cesar LA;Ramires, JF;Hueb, W;KRIEGER, Jose Eduardo;.Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization.Thrombosis Research,v.121,25 - 32,2007;
  16. MIYAKAWA, Ayumi Aurea;BORIN, Thaiz Ferraz;CAMPOS, Luciene Cristina Gastalho;CTENAS, Bruno Brito;DALLAN, Luís Alberto Oliveira;OLIVEIRA, Sérgio de Almeida;KRIEGER, José Eduardo;.Interleukin-1 Beta and Early Vascular Degeneration in Arterialized Human Saphenous Vein.Aterosclerosis Thrombosis And Vascular Biology,v.25,E-87,2005;
  17. Xavier-Neto, J.;PEREIRA, A. C.;OLIVEIRA, E. M.;MIYAKAWA, Ayumi Aurea;JUNQUEIRA, M. L.;KRIEGER, José Eduardo;.Control of the rat angiotensin I converting enzyme gene by CRE-like sequences.Brazilian Journal of Medical and Biological Research,v.37,1441 - 1453,2004;
  18. MIYAKAWA, Ayumi Aurea;JUNQUEIRA, M. L.;KRIEGER, José Eduardo;.Identification of two novel shear stress responsive elements in rat angiotensin I converting enzyme promoter.Physiological Genomics,v.17,107 - 117,2004;
  19. MIYAKAWA, Ayumi Aurea;KRIEGER, José Eduardo;.Identification of two novel shear stress responsive elements in the rat angiotensin-I converting enzyme promoter.Circulation,v.108,IV266,2003;
  20. PERTRINI, C. M.;MIYAKAWA, Ayumi Aurea;LAURINDO, F. R. M.;KRIEGER, José Eduardo;.Nitric oxide regulates angiotensin-I converting enzyme under static conditions but not under shear stress..Brazilian Journal of Medical and Biological Research,v.36,1175 - 1178,2003;
  21. COSTA-NETO, C. M.;MIYAKAWA, Ayumi Aurea;PESQUERO, J. B.;OLIVEIRA, L.;HJORTH, S. A.;SHWARTZ, T. W.;PAIVA, A. C. M.;.Interaction of a non-peptide agonist with angiotensin II AT1 receptor mutants.Canadian Journal of Physiology and Pharmacology,v.80,413 - 417,2002;
  22. COSTA-NETO, C. M.;MIYAKAWA, Ayumi Aurea;OLIVEIRA, L.;HJORTH, S. A.;PAIVA, A. C. M.;SHWARTZ, T. W.;.Mutational analysis of the interaction of N- and C-terminal ends of angiotensin II with the AT(1) receptor..British Journal of Pharmacology,v.130,1263 - 1268,2000;
  23. PELMAN, S.;COSTA-NETO, C. M.;MIYAKAWA, Ayumi Aurea;SCHAMBY, H. T.;HJORTH, S. A.;RIVERO, R. A.;GREEMLEE, W. J.;SHWARTZ, T. W.;.Dual agonistic and antagonistic property of nonpeptide angiotensin AT1 ligants: susceptibility to receptor mutations.Molecular Pharmacology,v.51,301 - 311,1997;