Matheus Malta de Sá

Short Bio

Bachelor's at Pharmaceutical Sciences from Universidade de São Paulo (2009), PhD in Medicinal Chemistry (2014), having spent one year at the Massachusetts Institute of Technology - MIT (USA). Has experience in Medicinal Chemistry, focusing on Molecular Dynamics Simulation, Multivariate Data Analysis (Hierarchic Cluster Analysis and Principal Component Analysis), QSAR and molecular docking, working mainly on the elucidation of alkylphosphocholines mechanism of actions and biophysics of lipid bilayers.

Line of Investigation

  • Modelagem molecular aplicada à elucidação dos mecanismos envolvidos na ação antiproliferativa e hemolítica das alquilfosfocolinas
  • Aplicação de QSPR-2D para prever a penetração através da barreira hematoencefálica de fármacos que agem no sistema nervoso central
  • Estudo conformacional do receptor AT1 de angiotensina II sob tensão de cisalhamento por dinâmica molecular e mutação sítio dirigida
  • Estudo da interação da miltefosina com bicamadas lipídicas com simulações de dinâmica molecular e modelo coarse-grained

Publications

  1. PACHIONI, J. A.;MAGALHAES, J. G.;LIMA, E. J. C.;BUENO, L. M.;BARBOSA, J. F.;SÁ, M. M.;RANGEL-YAGUI, C. O.;.Alkylphospholipids a promising class of chemotherapeutic agents with a broad pharmacological spectrum. Journal of Pharmacy & Pharmaceutical Sciences. Journal of Pharmacy & Pharmaceutical Sciences,v.16,742,2013;
  2. DE'SÁ, MATHEUS MALTA;PASQUALOTO, KERLY FERNANDA MESQUITA;MODESTIA, SILVESTRE MASSIMO;RANGEL-YAGUI, CARLOTA O.;.Alkylphosphocholines as Promising Antitumor Agents: Exploring the Role of Structural Features on the Hemolytic Potential. Molecular Informatics,v.33,53 - 64,2014;
  3. SÁ, M. M.;PASQUALOTO, K. F. M.;RANGEL-YAGUI, C. O.;.A 2D-QSPR approach to predict blood-brain barrier penetration of drugs acting on the central nervous system. RBCF. Revista Brasileira de Ciências Farmacêuticas (Cessou em 2008. Cont. ISSN 1984-8250 Brazilian Journal of Pharmaceutical Sciences),v.46,741 - 751,2010;