Paulo Caleb Junior de Lima Santos

Short Bio

Pesquisador Responsável por auxílio Jovem Pesquisador FAPESP, InCor 2013. Pós-doutorado pela Faculdade de Medicina da Universidade de São Paulo (USP-SP - 2013), no Laboratório de Genética e Cardiologia Molecular do Instituto do Coração do Hospital das Clínicas (InCor-HC/FMUSP). Doutor pelo Programa de Pós-Graduação da Faculdade de Ciências Farmacêuticas da USP-SP (CAPES 7 - 2011). Possui graduação em Farmácia-Bioquímica e habilitação em Análises Clínicas (ENADE-5, 2005, 2006) pela Universidade Federal de Alfenas, MG (UNIFAL-MG). Ganhador do Prêmio Jovem Geneticista 2011 pela Sociedade Brasileira de Genética. Responsável por auxílios CNPq. Atua como revisor ad hoc de diversos periódicos internacionais. Autor de capítulos de livros, coordenou publicações de livros pela Editora GEN-Roca e pela Atheneu (em processo). Orientador de Mestrado e Doutorado pelo Programa de Pós-Graduação em Ciências Médicas da FMUSP (CAPES 7). Docente de cursos de especialização Latu-Sensu. Possui experiências em Docência e em áreas de Pesquisa. Principais temas: diagnóstico molecular em doenças monogênicas, genoma, farmacogenética, metabolismo de ferro e hemocromatose hereditária. Estudos de associação genética em fenótipos bioquímicos, farmacológicos, hematológicos e cardiovasculares.

Publications

  1. Santos, Paulo Caleb Junior Lima;Krieger, Jose Eduardo;Pereira, Alexandre Costa;.Renin^|^ndash;Angiotensin System, Hypertension, and Chronic Kidney Disease: Pharmacogenetic Implications. Journal of Pharmacological Sciences,v.120,77 - 88,2012;
  2. Marcatto, L R;SACILLOTO, L.;DARRIEAUX, F. C. C.;HACHUL, D. T.;SCANAVACCA, M.;KRIEGER, Jose Eduardo;PEREIRA, AC;Santos, Paulo Caleb J.L.;.Age is associated with time in therapeutic range for warfarin therapy in patients with atrial fibrillation. OncoTarget,v.100,1,2016;
  3. BERNARDEZ-PEREIRA, SABRINA;Gioli-Pereira, Luciana;MARCONDES-BRAGA, FABIANA G;Santos, Paulo Caleb Junior Lima;SPINA, JOCELI MABEL ROCHA;HORIMOTO, ANDRÉA ROSELI VANÇAN RUSSO;SANTOS, HADASSA CAMPOS;BACAL, FERNANDO;FERNANDES, FÁBIO;MANSUR, ALFREDO JOSE;PIETROBON, RICARDO;Krieger, José Eduardo;MESQUITA, EVANDRO TINOCO;Pereira, Alexandre Costa;.Genomic ancestry as a predictor of haemodynamic profile in heart failure. Open Heart,v.3,e000434,2016;
  4. Santos, Paulo Caleb J.L.;SCHOLZ, JAQUELINE;BUZO, C.;LOPES, N.;ABE, TÂNIA OGAWA;GAYA, PATRICIA VIVIANE;PIERRI, H.;AMORIM, CLARICE;PEREIRA, AC;.Effects of aging on the effectiveness of smoking cessation medication. OncoTarget,v.100,1,2016;
  5. TOMAZ, P. R. X.;SANTOS, J. R.;Santos, Paulo Caleb J.L.;.Aspectos da aplicabilidade da análise da curva de melting. Revista Brasileira de Analises Clinicas,v.48,19 - 23,2016;
  6. FONSECA, PAULA FERNANDA SILVA;CANÇADO, RODOLFO DELFINI;UELLENDAHL LOPES, MARLY MARIA;CORREIA, EDILEIDE;LESCANO, MANUEL ANTONIO;Santos, Paulo Caleb Junior Lima;.HAMP Gene Mutation Associated with Juvenile Hemochromatosis in Brazilian Patients. Acta Haematologica,v.100,228 - 231,2016;
  7. ISSA, J. S.;Santos, Paulo Caleb J.L.;.Cost-effectiveness analysis of smoking-cessation treatment using electronic medical records in a cardiovascular hospital. Clinical Trials and Regulatory Science in Cardiology,v.14,1 - 3,2016;
  8. SILVA, ANDRÉ PACHECO;SCHOLZ, JAQUELINE;ABE, TANIA OGAWA;PINHEIRO, GABRIELA GOUVEIA;GAYA, PATRICIA VIVIANE;Pereira, Alexandre Costa;Santos, Paulo Caleb Junior Lima;.Influence of smoking cessation drugs on blood pressure and heart rate in patients with cardiovascular disease or high risk score: real life setting. BMC Cardiovascular Disorders (Online),v.16,1 - 6,2016;
  9. Santos, Paulo Caleb Junior Lima;Pereira, Alexandre Costa;.Type of LDLR mutation and the pharmacogenetics of familial hypercholesterolemia treatment. Pharmacogenomics (London),v.16,1743 - 1750,2015;
  10. TOMAZ, PAULO ROBERTO XAVIER;SANTOS, JULIANA ROCHA;ISSA, JAQUELINE SCHOLZ;ABE, TÂNIA OGAWA;GAYA, PATRÍCIA VIVIANE;Krieger, José Eduardo;Pereira, Alexandre Costa;SANTOS, PAULO CALEB JÚNIOR LIMA;.CYP2B6 rs2279343 polymorphism is associated with smoking cessation success in bupropion therapy. European Journal of Clinical Pharmacology,v.100,1-15,2015;
  11. Santos, Paulo Caleb Junior Lima;.Variables Related to Iron Status and Genetic Background Among Korean Populations: Ironing Out the Differences. Digestive Diseases and Sciences,v.100,1-3,2015;
  12. Mari Cardena;Andrea Ribeiro-dos-Santos;Sidney Santos;Sabrina BERNARDEZ-PEREIRA;SANTOS, P. C. J. L;Alfredo Mansur;Alexandre Pereira;Cintia Fridman;.Mitochondrial and genomic ancestry are associated with etiology of heart failure in Brazilian patients. Journal of Human Hypertension,v.,120 - 123,2015;
  13. ALVIM, RAFAEL O.;CHEUHEN, MARCEL R.;MACHADO, SILMARA R.;SOUSA, ANDRÉ GUSTAVO P.;Santos, Paulo C.J.L.;.General aspects of muscle glucose uptake. Anais da Academia Brasileira de Ciências (Impresso),v.87,351 - 368,2015;
  14. CANÇADO, RODOLFO;MELO, MURILO REZENDE;DE MORAES BASTOS, ROBERTO;Santos, Paulo Caleb J.L.;GUERRA-SHINOHARA, ELIVIRA M;BALLAS, SAMIR K;CHIATTONE, CARLOS;.Deferasirox in patients with iron overload secondary to hereditary hemochromatosis: results of a 1-year Phase 2 study. European Journal of Haematology,v.100,n/a - n/a,2015;
  15. SANTOS, J. R.;TOMAZ, P. R. X.;PEREIRA, AC;SANTOS, P. C.;.CHRNA4 rs1044396 is associated with smoking cessation in varenicline therapy. Frontiers in Genetics,v.6,1 - 7,2015;
  16. SANTOS, P. C.;Marcatto, L R;nubia esteban;Renata A G Soares;STRUNZ, C. M. C.;SCANAVACCA, M.;Krieger, José Eduardo;PEREIRA, AC;.Development of a pharmacogenetic-based warfarin dosing algorithm and its performance in Brazilian patients: highlighting the importance of population-specific calibration. Pharmacogenomics (London),v.,1 - 12,2015;
  17. Santos, Paulo C.J.L.;MORGAN, ALINE C.;JANNES, CINTHIA E.;Krieger, José E.;Santos, Raul D.;Pereira, Alexandre C.;.The MYLIP p.N342S polymorphism is associated with response to lipid-lowering therapy in Brazilian patients with familial hypercholesterolemia. Pharmacogenetics and Genomics (Print),v.24,548 - 555,2014;
  18. BERNARDEZ-PEREIRA, SABRINA;SANTOS, PAULO;KRIEGER, JOSE;MANSUR, ALFREDO;PEREIRA, ALEXANDRE;.ACTN3 R577X polymorphism and long-term survival in patients with chronic heart failure. BMC Cardiovascular Disorders (Online),v.14,90,2014;
  19. COLARES, VINÍCIUS SARDÃO;TITAN, SILVIA MARIA DE OLIVEIRA;PEREIRA, ALEXANDRE DA COSTA;MALAFRONTE, PATRÍCIA;CARDENA, MARI M.;SANTOS, SIDNEY;Santos, Paulo C.;FRIDMAN, CÍNTIA;BARROS, RUI TOLEDO;WORONIK, VIKTÓRIA;.MYH9 and APOL1 Gene Polymorphisms and the Risk of CKD in Patients with Lupus Nephritis from an Admixture Population. Plos One,v.9,e87716,2014;
  20. Santos, Paulo CJL;BUENO, CAROLINA T;LEMOS, PEDRO A;Krieger, José E;Pereira, Alexandre C;.LPA rs10455872 polymorphism is associated with coronary lesions in Brazilian patients submitted to coronary angiography. Lipids in Health and Disease,v.13,74,2014;
  21. ISSA, JAQUELINE S.;Santos, Paulo C.J.L.;VIEIRA, LIS P.;ABE, TANIA O.;KUPERSZMIDT, CARLA S.;NAKASATO, MIYOKO;CARDOSO, ELISABETH;AMORIM, CLARICE;Pereira, Alexandre C.;.Smoking Cessation and Weight Gain in Patients with Cardiovascular Disease or Risk Factor. International Journal of Cardiology (Print),v..,.,2014;
  22. DINARDO, CARLA LUANA;Santos, Paulo Caleb Junior Lima;SCHETTERT, ISOLMAR TADEU;Soares, Renata Alonso Gadi;Krieger, Jose Eduardo;Pereira, Alexandre Costa;.Investigation of Genetic Disturbances in Oxygen Sensing and Erythropoietin Signaling Pathways in Cases of Idiopathic Erythrocytosis. Genetics Research International,v.2013,1 - 4,2013;
  23. SANTOS, P. C. J. L.;MORGAN, A.;Cintia Elin Lepski;Luciana Turolla;Krieger, José Eduardo;Santos, Raul D.;PEREIRA, AC;.Presence and type of low density lipoprotein receptor (LDLR) mutation influences the lipid profile and response to lipid-lowering therapy in Brazilian patients with heterozygous familial hypercholesterolemia. Atherosclerosis (Amsterdam),v.233,206 - 210,2014;
  24. KANASHIRO, D. H.;GAMEIRO, F. D.;C JUNIOR, V. L.;SILVA, A. M.;R NETO, L. M.;JANUARIO, S.;MATSUI, R.;SANTOS, P. C. J. L.;.INTERFERÊNCIAS EM EXAMES LABORATORIAIS: CRITÉRIO DIAGNÓSTICO PARA O DIABETES MELLITUS E PRINCIPAIS FÁRMACOS HIPOGLICEMIANTES. Pharmacia Brasileira,v.25,163 - 168,2013;
  25. SANTOS, P. C. J. L.;Alvim, R O;MUSSO, M. M.;Cunha, R. d. S.;KRIEGER, Jose Eduardo;MILL, JOSE GERALDO;PEREIRA, AC;.Impact of diabetes mellitus on arterial stiffness in a representative sample of an urban Brazilian population. Diabetology & Metabolic Syndrome,v.5,45,2013;
  26. Santos, P C J L;Renata A G Soares;STRUNZ, C. M. C.;GRINBERG, M.;FERREIRA, J. F. M.;CESAR, L. A. M.;SCANAVACCA, M.;Krieger, José Eduardo;PEREIRA, AC;.Simultaneous use of amiodarone influences warfarin maintenance dose but is not associated with adverse events. J MANAGE CARE PHARM,v.20,1 - 6,2014;
  27. Soares, Renata Alonso Gadi;SANTOS, P. C.;Machado-Coelho, George Luiz Lins;NASCIMENTO, RAIMUNDO MARQUES DO;MILL, JOSE GERALDO;KRIEGER, Jose Eduardo;Pereira, Alexandre Costa;.CYP2C9 and VKORC1 Polymorphisms Are Differently Distributed in the Brazilian Population According to Self-Declared Ethnicity or Genetic Ancestry. Genetic Testing and Molecular Biomarkers (Online),v.16,957 - 963,2012;
  28. Gioli-Pereira, Luciana;SANTOS, P. C.;SUGAYA, LUISA S;Ferreira, Noely E;Krieger, José Eduardo;Pereira, Alexandre C;Hueb, Whady A;.Association between UCP2 A55V polymorphism and risk of cardiovascular events in patients with multi-vessel coronary arterial disease. BMC Medical Genetics (Online),v.14,40,2013;
  29. ALVIM, RAFAEL DE OLIVEIRA;Santos, Paulo C. J. L.;NASCIMENTO, RAIMUNDO M.;COELHO, GEORGE L. L. M.;Mill, José G.;Krieger, José E.;Pereira, Alexandre C.;.BDKRB2 +9/−9 Polymorphism Is Associated with Higher Risk for Diabetes Mellitus in the Brazilian General Population. Experimental Diabetes Research (Print),v.2012,1 - 4,2012;
  30. ISSA, J. S.;ABE, T. O.;MOURA, S.;SANTOS, P. C. J. L.;Pereira, A. C.;.Effectiveness of Coadministration of Varenicline, Bupropion, and Serotonin Reuptake Inhibitors in a Smoking Cessation Program in the Real-Life Setting. Nicotine & Tobacco Research,v.14,2 - 6,2012;
  31. Santos, Paulo Caleb Junior Lima;DINARDO, CARLA LUANA;SCHETTERT, ISOLMAR TADEU;Soares, Renata Alonso Gadi;KAWABATA-YOSHIHARA, LIZ;BENSENOR, ISABELA MARTINS;Krieger, José Eduardo;LOTUFO, PAULO ANDRADE;Pereira, Alexandre Costa;.CYP2C9 and VKORC1 polymorphisms influence warfarin dose variability in patients on long-term anticoagulation. European Journal of Clinical Pharmacology (Internet),v.68,100 - 110,2012;
  32. SANTOS, P. C. J. L.;Dinardo, Carla L.;Cançado, R.D.;Schettert, Isolmar T.;Krieger, J. E.;Pereira, Alexandre C;.Non-HFE hemochromatosis. Revista Brasileira de Hematologia e Hemoterapia (Impresso),v.34,311 - 316,2012;
  33. SANTOS, P. C. J. L.;OLIVEIRA, T. G. M.;LEMOS, P. A.;Mill, J. G.;Krieger, J E;Pereira, A C;.MYLIP p.N342S polymorphism is not associated with lipid profile in the Brazilian population. Lipids in health and disease,v.11,83,2012;
  34. GIOLI-PEREIRA, L.;Santos, P.C.J.L.;Ferreira, Noely E.;HUEB, W. A.;KRIEGER, JE;PEREIRA, AC;.Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21. BMC Cardiovascular Disorders (Online),v.12,61,2012;
  35. MACHADO SR;RODRIGUES, ALC;Silva, SC;Alvim, R O;SANTOS, P. C. J. L.;.Standardized nutritional intervention in hypoglycemic and hospitalized patients. Revista Gaúcha de Enfermagem (UFRGS. Impresso),v.33,64 - 68,2012;
  36. Alvim, R. d. O.;SANTOS, P. C. J. L.;Dias, R. G.;Rodrigues, M. V.;Cunha, R. d. S.;Mill, J. G.;Junior, W. N.;Krieger, J. E.;Pereira, A. C.;.Association between the C242T polymorphism in the p22phox gene with arterial stiffness in the Brazilian population. Physiological Genomics (Print),v.44,450 - 455,2012;
  37. Santos, P.C.J.L.;Cançado, R.D.;Terada, C.T.;Rostelato, S.;GONZALES, I.;Hirata, R.D.C.;Hirata, M.H.;Chiattone, C.S.;Guerra-Shinohara, E.M.;.HFE gene mutations and iron status of Brazilian blood donors. Brazilian Journal of Medical and Biological Research on line,v.43,107 - 114,2010;
  38. de Lima Santos, Paulo Caleb Júnior;Pereira, Alexandre C.;Cançado, Rodolfo D.;Schettert, Isolmar T.;Hirata, Rosario D.C.;Hirata, Mario H.;Figueiredo, Maria Stella;Chiattone, Carlos S.;Krieger, Jose E.;Guerra-Shinohara, Elvira M.;.Hemojuvelin and Hepcidin Genes Sequencing in Brazilian Patients with Primary Iron Overload. GENET TEST MOL BIOMA,v.14,803 - 806,2010;
  39. de Lima Santos, Paulo Caleb Júnior;de Oliveira Alvim, Rafael;Ferreira, Noely Evangelista;de Sá Cunha, Roberto;Krieger, José Eduardo;Mill, José Geraldo;Pereira, Alexandre Costa;.Ethnicity and Arterial Stiffness in Brazil. American Journal of Hypertension,v.24,278 - 284,2010;
  40. Santos, Paulo C. J. L.;Krieger, Jose E.;Pereira, Alexandre C.;.Molecular Diagnostic and Pathogenesis of Hereditary Hemochromatosis. International Journal of Molecular Sciences (Online),v.13,1497 - 1511,2012;
  41. Percy, Melanie J.;Chung, Yu Jin;Harrison, Claire;Mercieca, Jane;Hoffbrand, A. Victor;Dinardo, Carla L.;Santos, Paulo C.J.L.;Fonseca, Guilherme H.H.;Gualandro, Sandra F.M.;Pereira, Alexandre C.;Lappin, Terence R.J.;McMullin, Mary Frances;Lee, Frank S.;.Two new mutations in the HIF2A gene associated with erythrocytosis. American Journal of Hematology (Print),v.87,439 - 442,2012;
  42. Ferreira, Noely E.;Omae, Samantha;Pereira, Abel;Rodrigues, Mariliza V.;Miyakawa, Ayumi A.;Campos, Luciene C.G.;Santos, Paulo C.J.L.;Dallan, Luiz A.;Martinez, Tânia L.;Santos, Raul D.;Mill, José G.;Krieger, José E.;Pereira, Alexandre C.;.Thioredoxin interacting protein genetic variation is associated with diabetes and hypertension in the Brazilian general population. Atherosclerosis (Amsterdam),v.150,22,2011;
  43. Alvim, R O;Santos, P C J L;Ferreira, N E;Mill, J G;Krieger, J E;Pereira, A C;.Thioredoxin interacting protein (TXNIP) rs7212 polymorphism is associated with arterial stiffness in the Brazilian general population. Journal of Human Hypertension,v.24,1-3,2011;
  44. Santos, Paulo CJL;Soares, Renata AG;Nascimento, Raimundo M;Machado-Coelho, George LL;Mill, José G;Krieger, José E;Pereira, Alexandre C;.SLCO1B1 rs4149056 polymorphism associated with statin-induced myopathy is differently distributed according to ethnicity in the Brazilian general population: Amerindians as a high risk ethnic group. BMC Medical Genetics (Online),v.12,136,2011;
  45. Santos, Paulo Caleb Junior Lima;Gagliardi, Ana Carolina Moron;Miname, Márcio Hiroshi;Chacra, Ana Paula;Santos, Raul Dias;Krieger, Jose Eduardo;Pereira, Alexandre Costa;.SLCO1B1 haplotypes are not associated with atorvastatin-induced myalgia in Brazilian patients with familial hypercholesterolemia. European Journal of Clinical Pharmacology,v.18,sep,2011;
  46. Santos, Paulo Caleb Junior Lima;Soares, Renata Alonso Gadi;Krieger, Jose Eduardo;Guerra-Shinohara, Elvira Maria;Pereira, Alexandre Costa;.Genotyping of the hemochromatosis p.H63D and p.C282Y mutations by high-resolution melting with the Rotor-Gene 6000 instrument. Clinical Chemistry and Laboratory Medicine,v.49,- - -,2011;
  47. Santos, Paulo C.J.L.;Cançado, Rodolfo D.;Pereira, Alexandre C.;Schettert, Isolmar T.;Soares, Renata A.G.;Pagliusi, Regina A.;Hirata, Rosario D.C.;Hirata, Mario H.;Teixeira, Ana C.;Figueiredo, Maria Stella;.Hereditary hemochromatosis: Mutations in genes involved in iron homeostasis in Brazilian patients. Blood Cells, Molecules & Diseases (Print),v.,X - X,2011;
  48. Santos, Paulo CJL;Soares, Renata AG;Santos, Diogo GB;Nascimento, Raimundo M;Coelho, George LLM;Nicolau, Jose C;Mill, Jose G;Krieger, Jose E;Pereira, Alexandre C;.CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population. BMC Medical Genetics (Online),v.12,13,2011;
  49. ALVIM, RO;Freitas, SR;Ferreira, NE;Santos, Paulo Caleb J.L.;Cunha, RS;Mill, JG;Krieger, Jose Eduardo;PEREIRA, AC;.APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population. Lipids in health and disease,v.9,128,2010;
  50. Santos, Paulo C.J.L.;Pereira, Alexandre C.;Cançado, Rodolfo D.;Schettert, Isolmar T.;Sobreira, Tiago J.P.;Oliveira, Paulo S.L.;Hirata, Rosario D.C.;Hirata, Mario H.;Figueiredo, Maria Stella;Chiattone, Carlos S.;.HFE gene mutations in patients with primary iron overload: Is there a significant improvement in molecular diagnosis yield with HFE sequencing?. Blood Cells, Molecules & Diseases (Print),v.45,302 - 307,2010;
  51. Santos, Paulo Caleb J.L.;Cançado, Rodolfo D.;Pereira, Alexandre C.;Chiattone, Carlos S.;Krieger, Jose Eduardo;Guerra-Shinohara, Elvira M.;.HJV Hemochromatosis, Iron Overload, and Hypogonadism in a Brazilian Man: Treatment with Phlebotomy and Deferasirox. Acta Haematologica,v.124,204 - 205,2010;
  52. TERADA, C. T.;SANTOS, P. C. J. L.;Cançado, R. D.;Rostelato, S.;Lopreato, F. R.;Chiattone, C. S.;Guerra-Shinohara, E. M.;.Iron deficiency and frequency of HFE C282Y gene mutation in Brazilian blood donors. Transfusion Medicine (Print),v.19,245 - 251,2009;
  53. Santos, Paulo C. J. L.;Cançado, Rodolfo D.;Terada, Cristiane T.;Guerra-Shinohara, Elvira M.;.Alterações moleculares associadas à hemocromatose hereditária. Revista Brasileira de Hematologia e Hemoterapia (Impresso),v.31,192 - 202,2009;